Now do not ask me how I know it works but it is a good companion to my other medicines....ALTACE, VYTORIN, TOPROL, PAVLIX. NIASPAN. My blood tests prove that I am doing remarkably well....LDL is down to 20, blood pressure is 110-60. So after three heart attacks and one stroke in the last five years I am told by my Physician I am in excellent health. CoQ10 is a gift to my good health.