TMG is a godsend. When I went off antidepressants rather suddenly and was fishing around for something to stop panic attacks and intense bad moods, TMG was the first consistent improvement. Four years later, it is still an indispensable part of my regimen. Perhaps its most important effect is recycling homocysteine into SAMe, which has antidepressant effects. Unchecked homocysteine sensitizes neurons to glutamate toxicity, and probably harms new neurons trying to grow in the hippocampus. Other B-vitamins have also helped me, especially B-2 and B-6 (pyridoxamine), along with fish oil and a non-choline source of uridine (for example magnesium orotate, or triacetyluridine). Some of these will help migraines and focus along with mood. I take 500 to 1000 mg TMG a day; much more may raise cholesterol. Don't mix with acetyl-l-carnitine (and in fact, if you're depressive, I'd advise against acetyl-l-carnitine altogether, thanks to its acetylcholinergic activity). TMG raises carnitine levels itself, and has a mild choline sparing effect. SAMe, by the way, is similar but not so safe; the surge in SAMe levels will create a surge in homocysteine. I tried combining the two, hoping TMG would recycle the homocysteine back SAMe, but I've found TMG on its own most stabilizing and effective.

This has a less noticeable memory effect for me than alpha-GPC, but I like the fact it has uridine in it. Unfortunately, the uridine doesn't balance the pro-depressant effects of choline, and I can't take either CDP-choline or alpha-GPC (or for that matter any other supplementary choline) for more than a week without getting down and hopelessly ruminating. Bacopa is a better memory supplement for depressives. (I use the Planetary Herbals product to great benefit.) If you want to spare the choline you get from your diet, taking TMG will do that with a durable mood lift. Some of the body's choline is usually converted to TMG, so extra TMG frees choline to do other work, and meanwhile TMG makes SAMe, which is antidepressant. Both CDP-choline and TMG theoretically could help mood and memory in depression; in practice TMG helps mood, and CDP-choline hurts it, and neither does much for memory. Try bacopa, EPA, and magnesium orotate (or other uridine supplement) for memory in case of depression.

Bacopa truly is wonderful. If you have depression-related memory problems, it just may make your life more coherent and optimistic, as it has mine. I work as a tutor and have noticed a big difference in what I remember with little effort.

I have no idea why, but every time I tried taking this, my mood would tank. The product looks excellent in theory; on and off, I went through two bottles. As a result I almost gave up on tocotrienols, but then I tried Jarrow's Toco-Sorb, which has very little tocopherol. If anything my mood *improved* with that product. I am interested primarily in the neuroprotective properties of tocotrienols.

My sole concern about this supplement is how much natto gets through in the pills. If you take vitamin D3 oil capsules (which you probably should), be smart and take vitamin K2/MK-7 as well. The longer-chain forms of the vitamin stay in the blood longer and have recently been found more effective in one or two applications, including against prostate cancer. If someone tells you the *real* way to get K2 is to eat lots of butter and cheese, smile and explain that good isn't always best. This is the best.

Let's be honest: I like Jarrow. This stuff might be the same as any other creatine, but it works. I opted against the micronized form, since most of the research ascribes perfectly good effects to the regular monohydrate. What I do know is that creatine helps me with recovery, and I feel comfortable with half a scoop to a whole scoop a day, but I only do this intermittently. I've noticed during marathon study sessions that creatine can give a small burst of mental clarity and wakefulness. I believe this is a matter of direct and stable fuel for neurons, but I'm not sure. Creatine is considered neuroprotective, but as in all things, moderation is golden.

A little pricey, but the quality is very good. I personally found the very-low DHA, high EPA fish oils more effective for depression, but not so much that they fit in my shoestring budget. This is what I'd be taking if they did; I'm using Country Life's Omega 3 Mood until algal EPA saves the planet with low pricing.

Tried a bottle on and off for mood and memory, noticed a worsening of mood, as with choline supplements. This makes me believe PS does something, but it's not what I need, and my memory didn't improve. I highly recommend bacopa instead, for example the product from Planetary Herbals.

Does have a noticeable effect on fine wrinkles, whether you take it internally for weeks or apply it topically for days. The effect disappears quickly once you stop, and I don't entirely trust the safety of this compound beyond what I get from eating generous helpings of wild salmon. Still I believe you get what's advertised here; I'm only holding out for more research.

This appears to be going off the market. Excellent stuff--I'm building a stockpile while I can. The migraine benefit may come from the tendency of vitamin B-6 to increase the ratio of GABA to glutamate (the ratio runs low in migraineurs and epileptics). Do not combine more than 50 mg a day with nortriptyline, or your head will start going fuzzy and you'll make lots of arithmetic errors. There is a listed interaction, but I know not everyone checks.

While I'd prefer magnesium taurinate with additional magnesium, this'll do and it's cheaper! Currently I take magnesium for general health and to keep migraines at bay. Though I'm not sure how much the magnesium or taurine does for migraines, I do know that my supplement regimen (key: butterbur extract, product: Migra-Eeze) and some care about dietary triggers has almost eliminated my migraines, which I was getting almost every other day. Now, often a tisane of bay leaves and ginger will do what it took 800 mg ibuprofen and 1.5 g acetaminophen, or sometimes an Imitrex or two, to do before. The headaches are milder and rarer and shorter. Magnesium plays some part in this. The price and brand are right.

I took one every other day to counteract the CoQ10 depletion caused by nortriptyline. While it could be my imagination or something else, the nortriptyline seemed to become more effective at controlling migraines.